Tag: Parkinson’s disease
Eighty percent of people with Parkinson’s develop dementia within 20 years of their diagnosis. In a recent article in Science Daily, I learned that researchers discovered that the genetic variant APOE4 spurs the spread of harmful clumps of Parkinson’s proteins through the brain. Findings suggest that therapies that target APOE might reduce the risk of dementia for people diagnosed with Parkinson’s disease.
In making the above-noted finding, scientists at Washington University School of Medicine in St. Louis, analyzed publicly available data from three separate sets of people with Parkinson’s. It was found that cognitive skills declined faster in people with APOE4 than those with APOE3. People with APOE2, showed no cognitive decline over the period of the study.
Although APOE does not affect the overall risk of developing Parkinson’s or how quickly movement symptoms worsen, an APOE-targeted therapy might stave off dementia, the researchers suggest.
We often blog on the issue of dementia as it affects many aspects of our practice as estate litigators. It is always encouraging to read about a positive study or breakthrough in the area of this debilitating disease.
To learn more about this study, please consider visiting here.
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After Alzheimer’s Disease, Lewy body Dementia (LBD) is one of the leading causes of dementia in the elderly, accounting for up to 20% of cases of dementia.
In Lewy body Dementia, abnormal protein structures called Lewy bodies develop in regions of the brain responsible for thinking and movement. These Lewy bodies were first described in 1912 by Friederich Lewy, a colleague of Alois Alzheimer.
LBD symptoms closely resemble those of both Alzheimer’s disease and Parkinson’s disease. The Alzheimer’s-like symptoms of LBD include fluctuating levels of attention and alertness, and a progressive loss of memory, language, reasoning and higher mental functions such as calculation. The Parkinson’s-like symptoms of LBD include rigidity, stiffness, stooped posture and a shuffling gait. Complex, well-formed, but oddly unthreatening visual hallucinations are one of the earliest and most common (>80% incidence) symptoms of LBD and usually consist of people, children or animals.
Here are some more quick facts about LBD:
· LBD is slightly more common in men than women. The average age of onset is 75 to 80 years of age.
· There is no single test to diagnose LBD. Like Alzheimer’s disease, a diagnosis of LBD is considered ‘possible’ or ‘probable’ after other possible diagnoses are considered and eliminated.
· Lewy body Dementia usually has a rapid onset and rapid progression. The average span of time between diagnosis and death is about 5 to 7 years.
· There are no know therapies to slow the progression of LBD, nor is there a known cure. The goal of treatment is to control the cognitive, psychiatric and motor symptoms of the patient.
Jennifer Hartman, Guest Blogger